Theoretical Biophysics
Responsible: Prof. Frank Jülicher
Hours per week (2 +1 h)
Language: English
Topics:
Physics of bio-molecules: Basic concepts of statistical mechanics,
Mechanics of biopolymers, mechanics of DNA, optical tweezers and their calibration.Physics of fluid membranes: Differential geometry of surfaces, bending energy,
Gaussian fluctuations of membranes, entropic repulsion, entropic
elasticity of membranes, persistence length, physics of vesicles and
membrane tubes.Stochastic dynamical processes: Random walk and
diffusion, Langevin and Smoluchowsky equations. Correlation and
response. Dynamic correlation and response functions of the
harmonic oscillator, example: bead in optical trap. Fluctuation-Dissipation
theorem. Stochastic processes in periodic potentials, Kramers rates
over barriers. Discrete hopping models. Active processes.Motor proteins: two-state model for motor proteins. Physics of mechano-chemical
energy transductions, Collective behaviors of motor molecules in integrated systems.Dynamic phase transitions and Spontaneous oscillations.