Methods
- Liquid Chromatography
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High and ambient temperature size exclusion chromatography (SEC) for determination of molar mass distributions in organic and aqueous media in analytical or preparative scale.
High-Performance Liquid Chormatography (HPLC) is applied for the purification and qunatification of proteins and other substances.
- Gas Chromatography
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Classical, head-space and pyrolysis gas chromatography (GC) coupled with mass spectrometry is applied for qualitative determination of volatile compounds.
- Field-Flow Fractionation
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Asymmetrical flow field-flow fractionation (AF4) and thermal field-flow fractionation (ThFFF) is applied as column-free technique for the separation and characterization of complex polymers and macromolecules in the range of 101– 106 kg/mol.
- Detection Techniques
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Multidetection techniques based on scattering, spectroscopy, spectrometry, viscosity and other properties for orthogonal structure analysis
Expertise
- Advanced characterization
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Separation, quantification and identification of complex macromolecular samples, determination of molecular properties such as molar masses, dimensions, composition, branching, viscosity
- In-situ studies
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Investigation of:
- intra- or intermolecular interactions,
- drug-delivery studies (loading and release) of macromolecular and hybrid/conjugate structures
- Conformation analysis
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Scaling properties and shape information of macromolecules in solution, depending on outer environment (such as solvent, pH, salt, temperature, existence of other compounds)
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