Sponsor:
DFG

Founded project partners:
- Institut für Werkstoffwissenschaft der Technischen Universität Dresden (IFWW), 01062 Dresden
- Leibniz-Institut für Polymerforschung Dresden e. V. (IPF), 01069 Dresden

Coworkers:
Thomas Hanke (IFWW)
Dr. Frank Simon

Duration:
2011 - 2013

Abstract:
The aim of the studies is the improvement of the well-known biocompatible properties of the biopolymer chitosan. In order to use chitosan as temporary bone replacement material the following tasks were processed:

• Using chitosan filament yarns textile scaffolds of predetermined architecture were produced by embroidery technology.
• The surface of the textile scaffold pieces were modified by introduction of organically bonded sulfate and phosphate groups. The modification reactions were carried out without involving the chitosan's primary amino groups. The potential of the introduced sulfate and phosphate groups on the binding, concentration and release behavior of the growth factors BMP2 and VEGF were evaluated.
• The effects of untreated, surface-modified and growth factors-modified scaffolds on individual and co-cultures of hMSC/osteoblasts and monocytes/osteoclasts were examined. The results were compared to that of freeze-dried porous chitosan scaffolds.
• The degradation behavior of untreated and surface-modified chitosan scaffolds were investigated in enzyme-free and lysozyme-containing solutions. The influence of dissolved chitosan degradation products on individual and co-cultures of hMSC/osteoblasts and monocytes/osteoclasts was investigated.