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Dr. Petra Welzel

Institute of Biofunctional Polymer Materials
+49 351 4658 584 +49 351 4658 533

Fields of Work

  • co-speaker of the research area Matrix & Tissue Engineering
  • development of cell-instructive macroporous and multiphasic hydrogel materials for new therapeutic concepts as well as for advanced tissue and disease models
  • adsorption of proteins at solid/liquid interfaces

 

 

Publications

  • Grimus, S.; Sarangova, V.; Welzel, P. B.; Ludwig, B.; Seissler, J.; Kemter, E.; Wolf, E.; Ali, A. Immunoprotection strategies in β-cell replacement therapy: a closer look at porcine islet xenotransplantation more Advanced Science 11 (2024) 2401385
  • Ludwig, B.; Heller, C.; Sarangova, V.; Welzel, P. B. Islet macroencapsulation: strategies to boost islet graft oxygenation more Pluripotent Stem Cell Therapy for Diabetes / L. Piemonti et al. (Eds.). Cham : Springer, 2024. 251-280; ISBN 978-3-031-41942-3
  • Heller, C.; Rosenberger, C.; Sarangova, V.; Welzel, P. B.; Ludwig, B. Microarrangement of islets to prevent hypoxia within a macroencapsulation device more Transplantation 107 (2023) 62-62
  • Sarangova, V.; Heller, C.; Ludwig, B.; Welzel, P.; Werner, C. Strategies to improve islet survival and function in macroencapsulation devices for the treatment of patients with type I diabetes more Transplantation 107 (2023) 30-30
  • Sievers, J. ; Mahajan, V. ; Welzel, P.B. ; Werner, C. ; Taubenberger, A. Precision hydrogels for the study of cancer cell mechanobiology more Advanced Healthcare Materials 12 (2023) 2202514
  • Martínez-Vidal, L. ; Magno, V. ; Welzel, P. ; Friedrichs, J. ; Bornhäuser, M. ; Werner, C. Combining cryogel architecture and macromolecular crowding-enhanced extracellular matrix cues to mimic the bone marrow niche more Macromolecular Chemistry and Physics 224 (2023) 2200348
  • Sievers, J. ; Zimmermann, R. ; Friedrichs, J. ; Pette, D. ; Limasale, Y. D. P. ; Werner, C. ; Welzel, P. Customizing biohybrid cryogels to serve as ready-to-use delivery systems of signaling proteins more Biomaterials 278 (2021) 121170
  • Newland, B. ; Newland, H. ; Lorenzi, F. ; Eigel, D. ; Welzel, P. ; Fischer, D. ; Wang, W. ; Freudenberg, U. ; Rosser, A. ; Werner, C. Injectable glycosaminoglycan-based cryogels from well-defined microscale templates for local growth factor delivery more ACS Chemical Neuroscience 12 (2021) 1178-1188
  • Eigel, D. ; Schuster, R. ; Männel, M. J. ; Thiele, J. ; Panasiuk, M.J. ; Andreae, L. C. ; Varricchio, C. ; Brancale, A. ; Welzel, P. ; Huttner, W. B. ; Werner, C. ; Newland, B. ; Long, K. R. Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures more Biomaterials 271 (2021) 120712
  • Newland, B. ; Varricchio, C. ; Körner, Y. ; Hoppe, F. ; Taplan, C. ; Newland, H. ; Eigel, D. ; Tornillo, G. ; Pette, D. ; Brancale, A. ; Welzel, P. ; Seib, F. P. ; Werner, C. Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis more Carbohydrate Polymers 245 (2020) 116504
  • Alghamdi, M. ; Chierchini, F. ; Eigel, D. ; Taplan, C. ; Miles, T. ; Pette, D. ; Welzel, P. ; Werner, C. ; Wang, W. ; Neto, C. ; Gumbleton, M. ; Newland, B. Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme more Nanoscale Advances 2 (2020) 4498-4509
  • Schirmer, L. ; Hoornaert, C. ; Le Blon, D. ; Eigel, D. ; Neto, C. ; Gumbleton, M. ; Welzel, P. ; Rosser, A. ; Werner, C. ; Ponsaerts, P. ; Newland, B. Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain more Biomaterials Science 8 (2020) 4997-5004
  • Kühn, S. ; Sievers, J. ; Stoppa, A. ; Träber, N. ; Zimmermann, R. ; Welzel, P. ; Werner, C. Cell-instructive multiphasic gel-in-gel materials more Advanced Functional Materials 30 (2020) 1908857
  • Newland, B. ; Ehret, F. ; Hoppe, F. ; Eigel, D. ; Pette, D. ; Newland, H. ; Welzel, P. ; Kempermann, G. ; Werner, C. Static and dynamic 3D culture of neural precurso cells on macroporous cryogel microcarriers more MethodsX 7 (2020) 100805
  • Newland, B. ; Hoppe, F. ; Ehret, F. ; Newland, H. ; Eigel, D. ; Welzel, P. ; Kempermann, G. ; Werner, C. Macroporous heparin-based microcarriers allow long-term 3D culture and differentiation of neural precursor cells more Biomaterials 230 (2020) 119540
  • Husman, D. ; Welzel, P. ; Vogler, S. ; Bray, L. ; Träber, N. ; Friedrichs, J. ; Körber, V. ; Tsurkan, M. ; Freudenberg, U. ; Thiele, J. ; Werner, C. Multiphasic microgel-in-gel materials to recapitulate cellular mesoevironments in vitro more Biomaterials Science 2020 (2020) 101-108
  • Eigel, D. ; Zoupi, L. ; Sekizar, S. ; Welzel, P. ; Werner, C. ; Williams, A. ; Newland, B. Cryogel scaffolds for regionally constrained delivery of lysophosphatidylcholine to central nervous system slice cultures: A model of focal demyelination for multiple sclerosis research more Acta Biomaterialia 97 (2019) 216-229
  • Bray, L. ; Secker, C. ; Murekatete, B. ; Sievers, J. ; Binner, M. ; Welzel, P. ; Werner, C. Three-dimensional in vitro hydro- and cryogel-based cell-culture models for the study of breast-cancer metastasis to bone more Cancers 10 (2018) ID292
  • König, U. ; Psarra, E. ; Guskova, O. ; Bittrich, E. ; Eichhorn, K.-J. ; Müller, M. ; Welzel, P. ; Stamm, M. ; Uhlmann, P. Bioinspired thermoresponsive nanoscaled coatings: Tailor-made polymer brushes with bioconjugated arginine-glycine-aspartic acid-peptides more Biointerphases 13 (2018) ID021002
  • Bachmann, D. ; Aliperta, R. ; Bergmann, R. ; Feldmann, A. ; Koristka, S. ; Arndt, C. ; Loff, S. ; Welzel, P. ; Albert, S. ; Kegler, K. ; Ehninger, A. ; Cartellieri, M. ; Ehninger, G. ; Bornhäuser, M. ; Bonin, M. v. ; Werner, C. ; Pietzsch, J. ; Steinbach, Retargeting of UniCAR T cells with an in vivo synthesized target module directed against CD19 positive tumor cells more Oncotarget 9 (2018) ID23556, 14p.
  • Psarra, E. ; König, U. ; Müller, M. ; Bittrich, E. ; Eichhorn, K.-J. ; Welzel, P. ; Stamm, M. ; Uhlmann, P. In situ monitoring of linear RGD-Peptide bioconjugation with nanoscale polymer brushes more ACS Omega 2 (2017) 946-958
  • Aliperta, R. ; Welzel, P. ; Bergmann, R. ; Freudenberg, U. ; Berndt, N. ; Feldmann, A. ; Arndt, C. ; Koristka, S. ; Stanzione, M. ; Cartellieri, M. ; Ehninger, A. ; Ehninger, G. ; Werner, C. ; Pietzsch, J. ; Steinbach, J. ; Bornhäuser, M. ; Bachmann, M. Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy more Scientific Reports 7 (2017) Art.No. 42855
  • Borg, D. ; Welzel, P. ; Grimmer, M. ; Friedrichs, J. ; Weigelt, M. ; Wilhelm, C. ; Prewitz, M. ; Stißel, A. ; Hommel, A. ; Kurth, T. ; Freudenberg, U. ; Bonifacio, E. ; Werner, C. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells more Acta Biomaterialia 44 (2016) 178-187
  • Voit, B. ; Haag, R. ; Appelhans, D. ; Welzel, P. Bio- and multifunctional polymer architectures: Preparation, analytical methods, and applications more Wiley & Sons, Inc. (2016) 322 Seiten
  • Newland, B. ; Welzel, P. ; Newland, H. ; Renneberg, C. ; Kolar, P. ; Tsurkan, M. ; Rosser, A. ; Freudenberg, U. ; Werner, C. Tackling cell transplantation anoikis: An injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth more Small 11 (2015) 5047-5053