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Dr. Manfred Maitz

Institute of Biofunctional Polymer Materials
+49 351 4658 606/ 313 +49 351 4658 533

Personal Data

Manfred Maitz is responsible for the field of hemocompatible surfaces in the Institute Biofunctional Polymer Materials. He is a medical doctor (Dr. med.) by education and has been working on biomaterials research in institutes in Würzburg, Ulm, Magdeburg, Dresden and Chengdu (PR China) before he joined the IPF in 2006.

He is Guest Professor at Southwest Jiaotong University, School of Materials Science and Engineering in Chengdu, China, where he has annual research stays as guest scientist.

His focus of research is on feedback responsive materials to control blood coagulation and inflammatory responses at biomaterials in blood. These are important as vascular stents, artificial heart valves, hemodialysis membranes or tubings for extracorporeal circulation, etc.

He is member of the WTR in the IPF.

 Research experiences

2006 – presentResearch Fellow and Group Leader, Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Germany
2005Foreign Expert scientist, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China
2000 – 2004Thematic field leader, Research Center Rossendorf, Institute of Ion Beam Physics and Materials Research, Dresden, Germany
1999Assistant, Institute for Pathology, Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
1998Research Fellow, Central Institute of Biomedical Techniques, University of Ulm, Ulm, Germany

 Membership of Academic Societies

Profiles

Key Publications

  1. Maitz M.F., Zitzmann J., Hanke J., Renneberg C., Tsurkan M.V., Sperling C., Freudenberg U., Werner C. Adaptive release of heparin from anticoagulant hydrogels triggered by different blood coagulation factors. Biomaterials 135: 53-61 (2017). doi:10.1016/j.biomaterials.2017.04.044
  2. Herklotz M., Hanke J., Hänsel S., Drichel J., Marx M., Maitz M.F., Werner C. Biomaterials trigger endothelial cell activation in co-incubation with human whole blood. Biomaterials 104: 258-268 (2016). doi:10.1016/j.biomaterials.2016.07.022
  3. Maitz M.F. Applications of synthetic polymers in clinical medicine. Biosurf Biotribol 1(3): 161-176 (2015). doi:10.1016/j.bsbt.2015.08.002
  4. http://dx.doi.org/10.1016/j.bsbt.2015.08.002Maitz M.F., Freudenberg U., Tsurkan M.V., Fischer M., Beyrich T., Werner C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation. Nature Commun (2013). doi:10.1038/ncomms3168
  5. Sperling C., Fischer M., Maitz M.F., Werner C. Blood coagulation on biomaterials requires the combination of distinct activation processes. Biomaterials 30(27): 4447-4456 (2009). doi:10.1016/j.biomaterials.2009.05.044
  6. Werner C., Maitz M.F., Sperling C. Current strategies towards hemocompatible coatings. J Mater Chem 17: 3376-3384 (2007). doi:10.1039/b703416b

 

Publications

  • Chen, S. ; Zhang, J. ; Chen, Y. ; Zhao, S. ; Chen, M. ; Li, X. ; Maitz, M.F. ; Wang, J. ; Huang, N. Application of phenol/amine copolymerized film modified magnesium alloys: anticorrosion and surface biofunctionalization more ACS Applied Materials & Interfaces 7 (2015) 24510-24522
  • Maitz, M.F. Applications of synthetic polymers in clinical medicine more Biosurface and Biotribology 1 (2015) 161-176
  • Chen, H. ; Li, X. ; Zhao, Y. ; Li, J. ; Chen, J. ; Yang, P. ; Maitz, M.F. ; Huang, N. Construction of a multifunctional coating consisting of phospholipids and endothelial progenitor cell-specific peptides on titanium substrates more Applied Surface Science 347 (2015) 169-177
  • Chen, Y. ; Zhao, S. ; Chen, M. ; Zhang, W. ; Mao, J. ; Zhao, Y. ; Maitz, M.F. ; Huang, N. ; Wan, G. Sandwiched polydopamine (PDA) layer for titanium dioxide (TiO2) coating on magnesium to enhance corrosion protection more Corrosion Science 96 (2015) 67-73
  • Fischer, M. ; Vahdatzadeh, M. ; Konradi, R. ; Friedrichs, J. ; Maitz, M.F. ; Freudenberg, U. ; Werner, C. Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity more Biomaterials 56 (2015) 198-205
  • Zhang, H. ; Luo, R. ; Li, W. ; Wang, J. ; Maitz, M.F. ; Wang, J. ; Wan, G. ; Chen, Y. ; Sun, H. ; Jiang, C. ; Shen, R. ; Huang, N. Epigallocatechin gallate (EGCG) induced chemical conversion coatings for corrosion protection of biomedical MgZnMn alloys more Corrosion Science 94 (2015) 305-315
  • Chen, J. ; Li, Q. ; Xu, J. ; Zhang, L. ; Maitz, M.F. ; Li, J. Thromboresistant and rapid-endothelialization effects of dopamine and staphylococcal protein a mediated anti-CD34 coating on 316L stainless steel for cardiovascular devices more Journal of Materials Chemistry B 3 (2015) 2615-2623
  • Zhao, A. S. ; Wang, Z. ; Zhu, X. H. ; Maitz, M.F. ; Huang, N. Real-time characterization if fibrionogen interaction with modified titanium dioxide film by quartz crystal microbalance with dissipation more Chinese Journal of Chemical Physics 27 (2014) 355-360
  • Yang, Y. ; Qi, P. ; Ding, Y. ; Maitz, M.F. ; Yang, Z. ; Tu, Q. ; Xiong, K. ; Leng, Y. ; Huang, N. A biocompatible and functional adhesive amine-rich coating based on dopamine polymerization more Journal of Materials Chemistry B 3 (2014) 72-81
  • Wang, X. ; Liu, T. ; Chen, Y. ; Zhang, K. ; Maitz, M.F. ; Pan, C. ; Chen, J. ; Huang, N. Extracellular matrix inspired surface functionalization with heparin, fibronectin and VEGF provides an anticoagulant and endothelialization supporting microenvironment more Applied Surface Science 320 (2014) 871-882
  • Duryagina, R. ; Anastassiadis, K. ; Maitz, M.F. ; Gramm, S. ; Schneider, S. ; Wobus, M. ; Thieme, S. ; Brenner, S. ; Werner, C. ; Bornhäuser, M. Cellular reporter systems for high-throughput-screening of interactions between bioactive matrices and human mesenchymal stromal cells more Tissue Engineering Part C: Methods 20 (2014) 828-837
  • Yang, Y. ; Qi, P. ; Wen, F. ; Li, X. ; Xia, Q. ; Maitz, M.F. ; Yang, Z. ; Shen, R. ; Tu, Q. ; Huang, N. Mussel-inspired one-step adherent coating rich in amine groups for covalent immobilization of heparin: Hemocompatibility, growth behaviors of vascular cells, and tissue response more ACS Applied Materials & Interfaces 6 (2014) 14608-14620
  • Yang, Z. ; Zhong, S. ; Yang, Y. ; Maitz, M.F. ; Li, X. ; Tu, Q. ; Qi, P. ; Zhang, H. ; Qiu, H. ; Wang, J. ; Huang, N. Polydopamine-mediated ling-term elution of the direct thrombin inhibitor bivalirudin from TiO2 nanotubes for improved vascular biocompatibility more Journal of Materials Chemistry B 2 (2014) 6767-6778
  • Liu, T. ; Zeng, Z. ; Liu, Y. ; Wang, J. ; Maitz, M.F. ; Wang, Y. ; Liu, S. ; Chen, J. ; Huang, N. Surface modification with dopamine and heparin/poly-i-Lysine nanoparticles provides a favorable release behavior for the healing of vascular stent lesions more ACS Applied Materials & Interfaces 6 (2014) 8729-8743
  • Qi, P. ; Chen, S. ; Liu, T. ; Chen, J. ; Yang, Z. ; Weng, Y. ; Chen, J. ; Wang, J. ; Maitz, M.F. ; Huang, N. New strategies for developing cardiovascular stent surfaces with novel functions (Review) more Biointerphases [Elektronische Ressource] 9 (2014) 029017
  • Liu, T. ; Liu, Y. ; Chen, Y. ; Liu, S. ; Maitz, M.F. ; Wang, X. ; Zhang, K. ; Wang, J. ; Wang, Y. ; Chen, J. ; Huang, N. Immobilization of heparin/Poly-L-lysine nanoparticles on dopamine-coated surface to create a heparin density gradient for selective direction of platelet and vascular cells behavior more Acta Biomaterialia 10 (2014) 1940-1954
  • Chen, S. ; Li, X. ; Yang, Z. ; Zhou, S. ; Luo, R. ; Maitz, M.F. ; Zhao, Y. ; Wang, J. ; Xiong, K. ; Huang, N. A simple one-step modification of various materials for introducing effective multi-functional groups more Colloids and Surfaces B: Biointerfaces 113 (2014) 125-133
  • Wan, G. ; Lv, Bo ; Jin, G. ; Maitz, M.F. ; Zhou, J. ; Huang, N. Direct correlation of electrochemical behaviors with anti-thrombogenicity of semiconducting titanium oxide films more Journal of Biomaterials Applications 28 (2014) 719-728
  • Seib, P. ; Herklotz, M. ; Burke, K. ; Maitz, M.F. ; Werner, C. ; Kaplan, D. L. Multifunctional silk-heparin biomaterials for vascular tissue engineering applications more Biomaterials 35 (2014) 83-91
  • Wang, J. ; He, Y. ; Maitz, M.F. ; Collons, B. ; Xiong, K. ; Guo, L. ; Yun, Y. ; Wan, G. ; Huang, N. A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications: toward better biofunction, biodegradation and biocompatibility more Acta Biomaterialia 9 (2013) 8678-8689
  • Qi, P. ; Maitz, M.F. ; Huang, N. Surface modification of cardiovascular materials and implants more Surface & Coatings Technology 233 (2013) 80-90
  • Qi, P. ; Yang, Y. ; Maitz, M.F. ; Huang, N. Current status of research and application in vascular stents more Chinese Science Bulletin 58 (2013) 4362-4370
  • Schulze, A. ; Maitz, M.F. ; Zimmermann, R. ; Marquardt, B. ; Fischer, M. ; Werner, C. ; Went, M. ; Thomas, I. Permanent surface modification by electron-beam-induced grafting of hydrophilic polymers to PVDF membranes more Journal of Membrane Science 3 (2013) 22518-22526
  • Li, J. ; Li, G. ; Zhang, K. ; Liao, Y. ; Yang, P. ; Maitz, M.F. ; Huang, N. Co-culture of vascular endothelial cells and smooth muscle cells by hyaluronic acid micro-pattern on titanium surface more Applied Surface Science 273 (2013) 24-31
  • Huang, Q. J. ; Sun, H. ; Huang, N. ; Maitz, M.F. ; Brown, I. G. Formation of microcraters for gene transfer on plant cell walls by plasma immersion ion implantation more Surface & Coatings Technology 229 (2013) 197-199