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Paper "Interpenetrating polymer network hydrogels with tunable viscoelasticity and proteolytic cleavability to direct stem cells in vitro" published
The paper Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro by Prannoy Seth, Jens Friedrichs, Yanuar Dwi Putra Limasale, Nicole Fertala, Uwe Freudenberg, Yixin Zhang, Ayala Lampel, and Carsten Werner introduces novel, cell-instructive interpenetrating hydrogels based on sulfated glycosaminoglycans. These hydrogels feature tunable viscoelasticity, stiffness, and proteolytic cleavability to examine their influence on stem cell morphogenesis. The findings highlight that hydrogels with enhanced viscoelasticity and cleavability promote greater spreading of human mesenchymal stem cells and increased YAP (Yes-associated protein) activity. In contrast, human induced pluripotent stem cell cysts exhibit altered morphogenesis and matrix protein secretion while retaining pluripotency. This research provides valuable insights into designing advanced biomaterials that support complex and dynamic cell-matrix interactions. The paper was published in Advanced Healthcare Materials. DOI: 10.1002/adhm.202402656
26.11.2024